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Now Reading: Bidirectional disruption of GNAS transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B

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Bidirectional disruption of GNAS transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B

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Bidirectional disruption of GNAS transcripts causes broad methylation defects in pseudohypoparathyroidism type 1B

IO_AdminUncategorized2 months ago35 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 16, April 2025.
SignificancePseudohypoparathyroidism type 1B (PHP1B) is a disorder caused by end-organ hormone resistance due to epigenetic alterations atGNAS,a complex locus encoding Gsα as well as other sense and antisense RNAs. The promoters of these transcripts are …
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