Astrocytic cAMP Elevation Alters Cerebral Blood Flow Without Ca2+ Signaling in Mice

Quick Summary

• The article discusses research published in the Proceedings of the National Academy of Sciences (PNAS), Volume 122, Issue 27, july 2025.
• The study examines how astrocytes, specialized brain cells, regulate cerebral blood flow (CBF).
• Astrocytes respond too neuronal activity by increasing calcium (Ca2+) or cyclic adenosine monophosphate (cAMP) levels.

Indian Opinion Analysis
This research could have broader implications for neuroscience and healthcare innovation globally. Understanding how astrocytes regulate cerebral blood flow may lead to breakthroughs in managing neurodegenerative diseases and stroke. For India, which faces a meaningful burden of neurological disorders with limited access to advanced treatments in rural areas, such findings underscore the importance of investing in medical research collaborations and education to close gaps between cutting-edge science and its local application.

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