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BRAF oncogenic mutants evade autoinhibition through a common mechanism | Science
Uncontrolled activation of the rat sarcoma (RAS)–extracellular signal–regulated kinase (ERK) pathway drives tumor growth, often because of oncogenic BRAF mutations. BRAF regulation, involving monomeric autoinhibition and activation by dimerization, has
Prehistoric genomes from Yunnan reveal ancestry related to Tibetans and Austroasiatic speakers | Science
The human landscape in East and Southeast Asia is vastly complex, and successful retrieval of genome-wide data from prehistoric humans of southern East Asia is sparse. We successfully sampled 127
A single domestication origin of adzuki bean in Japan and the evolution of domestication genes | Science
Adzuki is a central legume in East Asian culinary culture, yet its domestication origin remains debated. Using ~700 accessions across Asia, we show that the initial domestication happened three to
Attenuation of virulence in Yersinia pestis across three plague pandemics | Science
Yersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulence gene pla
Conserved brain-wide emergence of emotional response from sensory experience in humans and mice | Science
Emotional responses to sensory experience are central to the human condition in health and disease. We hypothesized that principles governing the emergence of emotion from sensation might be discoverable through
Struggling To Lose Weight? Take Inspiration From Kusha Kapila’s Fitness Journey
Updated 1 June 2025 at 13:30 IST Kusha Kapila opened up about her drastic weight loss, revealing struggles in childhood, extreme dieting, and body image issues, which led to health
LPG Price June 2025: Commercial Cylinder Rates Slashed -Wise Prices for Delhi, June 2025: Commercial Cylinder Rates Slashed -Wise Prices for Delhi, Mumbai, Chennai, Kolkata
Updated 1 June 2025 at 13:50 IST After the third straight monthly cut in LPG prices, check out the latest rates across the top cities in India. Follow: LPG Prices
What’s Wrong With Amitabh Bachchan? Fans Worry As Actor Drops Cryptic Post On Leaving Loved Ones Behind
Updated 1 June 2025 at 11:44 IST Amitabh Bachchan has left his fans and well-wishers worried after he shared a cryptic note on his X (formerly Twitter). The 83-year-old actor
Norway Chess 2025: Reigning World Champion D Gukesh’s Shaky Run Continues After Defeat In Tie-Break, Slips To Joint 5th
Updated 1 June 2025 at 12:56 IST Norway Chess 2025: Reigning World Champion D Gukesh sufferes a heavy loss to China’s Wei Yi and has slipped to the Joint 5th
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