Breakthrough Cell Therapy Restores Insulin in Type 1 Diabetes Patient

Quick Summary

  • Researchers have developed a therapy for Type 1 diabetes using genetically modified insulin-producing cells that evade immune system attacks, possibly eliminating the need for immunosuppressants.
  • A groundbreaking case involved a 42-year-old diabetic patient who received nearly 80 million modified pancreatic beta cells injected into his arm. After three months, the cells survived, produced insulin, and avoided immune system rejection.
  • The therapy employs CRISPR gene-editing to remove immune-response markers and enhance anti-rejection genes in donor cells.
  • Early results show slight improvements in natural insulin production post-transplantation; however, the patient still requires external insulin supplementation as the transplanted cells only provided about 7% of his total needs.
  • Scientists are optimistic but caution that safety and efficacy must be confirmed through long-term monitoring and larger trials beyond this single participant study before wider usage is approved.

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