Conserved C143: A Key Intermediate in Hedgehog Pathway and Cancer Drug Discovery

Rapid Summary

• The Proceedings of the National Academy of Sciences, Volume 122, Issue 17 (April 2025), highlights insights into Hedgehog (Hh) signaling.
• hh signaling is critical for embryonic advancement and is linked too cancer when activated abnormally in adults.
• Despite the FDA approval of Hh-targeting drugs, rapid resistance to these treatments has emerged as a significant challenge.
• The article underscores the need for continued research into choice strategies to combat drug resistance in this context.

Indian Opinion Analysis
The findings from this research on Hedgehog (Hh) signaling are a reminder of India’s growing stake in global biomedical advancements.Given India’s active pharmaceutical industry and efforts to pioneer drug innovation, understanding mechanisms such as Hh signaling could drive new therapeutic breakthroughs domestically. Moreover, addressing drug resistance-a highlighted issue-should be a focal point for researchers here, aligning with India’s larger health challenges around noncommunicable diseases like cancer. This emphasizes the necessity for enhanced funding and collaboration between Indian academic institutions and industry players toward more targeted cancer solutions.

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