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Now Reading: CRBN Target Space Discovery Redefines Molecular Glue Neosubstrate Recognition

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CRBN Target Space Discovery Redefines Molecular Glue Neosubstrate Recognition

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CRBN Target Space Discovery Redefines Molecular Glue Neosubstrate Recognition

CRBN Target Space Discovery Redefines Molecular Glue Neosubstrate Recognition

IO_AdminUncategorized2 hours ago3 Views

The CRL4CRBN E3 ubiquitin ligase is the target of molecular glue degrader compounds that reprogram ligase specificity to induce the degradation of clinically relevant neosubstrate proteins. Known cereblon (CRBN) neosubstrates share a generalizable β…
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