Crystal structure and catalytic mechanism of drimenol synthase, an unusual bifunctional terpene cyclase–phosphatase

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Proceedings of the National Academy of Sciences, Volume 122, Issue 26, July 2025.
SignificanceTerpenoid natural products have featured prominently in the pharmacopoeia since times of antiquity. For example, C15sesquiterpenes are responsible for the analgesic effects of myrrh, historically prescribed as a painkiller in the Ebers …
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