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Now Reading: Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning

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Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning

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Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning

IO_AdminUncategorized18 hours ago1 Views

Proceedings of the National Academy of Sciences, Volume 122, Issue 25, June 2025.
SignificanceProtein structure–function relationships are critical for understanding molecular mechanisms and the impacts of genetic variation. We used deep dominant mutational scanning for sensitivity to DNA damage to find dominant negative and gain-of…
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