Innovative Peptide Binders Created from Protein Sequences

Speedy Summary

• Publication: Nature biotechnology, 18 August 2025.
• Research Highlight: PepMLM, a protein language model fine-tuned on protein-peptide data, can design linear peptides capable of binding and degrading proteins (e.g., cancer receptors, neurodegeneration drivers, viral proteins) without requiring structural data.
• Applications: The generated peptides show potential therapeutic relevance for targeting harmful proteins linked to various diseases.

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!https://www.nature.com/articles/s41587-025-02781-y