Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets

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Nature Biotechnology

(2025)Cite this article

Inspired by natural molecular glues, drug hunters are chasing protein–protein interactions with next-gen small molecules tuned for enhanced tissue specificity and reduced toxicity.

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Authors and Affiliations

  1. London, UK

    Megan Cully

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Competing interests

M.C. works part-time for Goat’s Eye Consulting; no company mentioned in this story is a client.

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Cite this article

Cully, M. Natural molecular glues spur next-gen small molecules for ‘undruggable’ targets.
Nat Biotechnol (2025). https://doi.org/10.1038/s41587-025-02779-6

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  • DOI: https://doi.org/10.1038/s41587-025-02779-6

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