Oxr1 and Ncoa7 Key to Regulating Golgi pH for Optimal Glycosylation

fast Summary

• The article discusses the secretory pathway within organelles and the gradual acidification of their pH levels.
• The process starts with a near-neutral pH (7.1 to 7.2) in the endoplasmic reticulum and decreases progressively in the Golgi apparatus/trans-Golgi network (pH 6.0 to 6.7).
• Ultimately, pH levels reach highly acidic conditions (4.5 to 5.0) at later stages of this pathway.

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Indian Opinion Analysis
The detailed analysis of organelle acidification through India-focused research can have broader implications for understanding cellular processes crucial for human health and biotechnology industries, which are growing sectors in India’s scientific landscape. This could lead to advancements in pharmaceuticals or other medical applications relevant globally but especially significant for India’s large population dealing with various health challenges requiring innovative solutions derived from fundamental science.