Ozempic: Could It Reverse Biological Aging?

Quick Summary

• Ozempic Benefits: The diabetes drug Ozempic, along with Wegovy, both containing semaglutide, may slow biological ageing and even reverse it in certain cases.
• New Evidence: A clinical trial with 108 participants (all with HIV-associated lipohypertrophy) revealed that those treated weekly with semaglutide for 32 weeks became biologically younger by an average of 3.1 years. In contrast, the placebo group saw no meaningful change.
• Specific organ Impact: Biological ageing slowed in organs like the heart, kidneys, brain (by up to five years), and inflammatory systems.Effects are thought to result from improved fat distribution and reduced inflammation.
• Mechanism of Action: The drug’s influence on metabolic health and its prevention of low-grade inflammation are cited as key reasons behind its anti-ageing effects.
• Broader Implications: Findings suggest similar benefits might extend beyond HIV-related conditions due to shared biological pathways.
• Expert Opinions:

– Randy Seeley (University of Michigan) emphasizes that benefits arise primarily from overall health improvements rather than direct cellular effects.- Varun Dwaraka (TruDiagnostic) notes it’s premature to prescribe semaglutide broadly for anti-ageing but highlights its promise in treating age-related issues through repurposed drugs.

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