Patulin and Xestoquinol Identified as DNA Topoisomerase 1 Inhibitors

Quick Summary

• The Proceedings of the National Academy of Sciences (PNAS), Volume 122, Issue 17 (april 2025), contains research focused on DNA topoisomerases.
• DNA topoisomerases play a vital role in maintaining DNA homeostasis by relieving torsional stress caused by the natural helicity of DNA.
• Their function is especially critical for highly proliferative cells.

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Indian Opinion Analysis
The research highlights a fundamental mechanism in cellular biology, focusing on how DNA topoisomerases alleviate structural strain in genetic material-a crucial function for rapidly dividing cells like those found in cancer and regenerative tissues. For india, advancements or discoveries tied to these mechanisms coudl foster innovations across healthcare and biotechnology sectors, potentially improving precision medicine and treatments for proliferative diseases such as cancer. Such insights emphasize India’s ongoing need to invest further in biological sciences and collaborative global research initiatives to stay competitive while addressing domestic challenges efficiently.