India has witnessed important strides in healthcare innovation over recent decades and follows global advancements closely. The progress in personalized mRNA-based cancer vaccine technology is particularly relevant as India continues its battle against increasing rates of cancer diagnoses. If accomplished, such advancements can transform how oncological treatments are approached globally-perhaps benefiting Indian patients through adapted, precision-based therapies. However,India’s capacity to adopt these technologies will hinge on affordability strategies and robust healthcare infrastructure development to make cutting-edge innovations accessible across socio-economic strata.