Rare Semen Allergy Linked to Woman’s Infertility: A Diagnostic Challenge

Quick Summary

• A 29-year-old woman in Lithuania faced unexplained infertility despite two failed IVF attempts and normal gynecological exams.
• The woman, who had a history of allergies, underwent tests that revealed extreme sensitivity to various allergens, including proteins found in dog dander and human semen.
• Allergy symptoms were confirmed during unprotected intercourse with her partner. Further testing diagnosed her with human seminal plasma allergy, which is rare but can contribute to infertility.
• Doctors suggested antihistamine medication as treatment due to the unavailability of desensitization therapy in Lithuania; however, this approach proved ineffective.
• Over three years, her allergic reactions worsened with new symptoms after exposure to semen.She remained unable to conceive.

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Indian Opinion Analysis

Rare cases like this emphasize the complexity of diagnosing and treating infertility issues when unusual medical conditions are involved. While instances of human seminal plasma allergy are exceedingly uncommon-only around 80 documented globally-it underscores the necessity for thorough multidisciplinary evaluations for couples experiencing unexplained infertility.

India’s growing healthcare infrastructure has been developing advanced diagnostic tools for reproductive health concerns. However, such rare disorders may still pose challenges due to their limited research base worldwide. collaboration between allergists and fertility specialists could offer better strategies for identifying non-conventional causes of infertility here while improving access to treatments such as desensitization therapies.

Moreover,increasing awareness among healthcare professionals regarding unconventional contributors like allergies could enhance patient outcomes in india’s expanding assisted reproduction industry while also educating prospective parents about prevention or mitigation strategies targeting similar conditions during pre-conception planning stages.