Trans-Subunit Interactions Key to DNA Cycle Regulation in Bacteriophage Φ29

Swift Summary

• The Proceedings of the National Academy of Sciences (PNAS) released its Volume 122, Issue 27 in July 2025.
• It highlights research on viral molecular mechanisms, specifically focusing on ring-shaped molecular motors that hydrolyze ATP.
• These motors are critical for translocating DNA or RNA genomes into viral capsids.
• Coordination between multiple subunits is essential to ensure proper sequencing and functionality of these processes.

Indian Opinion Analysis
The study underscores the intricate biological mechanisms employed by viruses during genome packaging, driven by ATP-powered molecular motors. This insight holds substantial implications for India’s public health and biotechnological sectors as it may influence innovations in antiviral therapies or diagnostic techniques for combating viral diseases common in the region.With global research advancing rapidly, India’s scientific community can benefit from engaging with such essential knowledge to address local challenges related to virology and healthcare infrastructure.

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